Image by iStock

By Aiden Pink January 11, 2018

Ashkenazi Jews with Crohn’s disease have an increased likelihood of carrying a gene mutation that causes Parkinson’s disease, a new scientific study has found.

The study, published in Science Translational Medicine, could help doctors better understand the causes of both Parkinson’s and Crohn’s, a disease causing chronic inflammation of the digestive system that is disproportionately prevalent among Ashkenazi Jews.

The decade-long study found that Ashkenazi Jews with Crohn’s are more likely to have the LRRK2 gene mutation, which the Michael J. Fox Foundation calls the greatest known genetic contributor to Parkinson’s.

Forwarding the News

Thoughtful, balanced reporting from the Forward and around the web, bringing you updated news and analysis each day.

Terms(Required)

I agree to the Forward's Terms of Service and Privacy Policy

Email(Required)

“The presence of shared LRRK2 mutations in patients with Crohn’s disease and Parkinson’s disease provides refined insight into disease mechanisms and may have major implications for the treatment of these two seemingly unrelated diseases,” explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

Dr. Peter and her colleagues analyzed 23,000 genetic mutations in 2,066 Ashkenazi Jews with Crohn’s and 3,633 Ashkenazi Jews who don’t have Crohn’s.

The analysis also found that Crohn’s patients with a riskier version of the LRRK2 mutation were more likely to develop Crohn’s in the small intestine, which is harder to treat. Crohn’s patients with the riskier LRRK2 mutation also developed the disease an average of six years earlier than patients who did not have that mutation.

Contact Aiden Pink at [email protected] or on Twitter, @aidenpink

The Forward is free to read, but it isn’t free to produce

I hope you appreciated this article. Before you go, I’d like to ask you to please support the Forward.

Now more than ever, American Jews need independent news they can trust, with reporting driven by truth, not ideology. We serve you, not any ideological agenda.

At a time when other newsrooms are closing or cutting back, the Forward has removed its paywall and invested additional resources to report on the ground from Israel and around the U.S. on the impact of the war, rising antisemitism and polarized discourse.

Readers like you make it all possible. We’re in the middle of our Passover Fundraising Drive, and we have a very ambitious goal of $127,000 by April 21.

This is a great time to support independent Jewish journalism you rely on. Make a Passover gift today!

—  Rachel Fishman Feddersen, Publisher and CEO

Make a Passover Gift Today!

$90 $180

$360

Other amount